icotrokinra

Modality

small molecule

Mechanism

12.1 Mechanism of Action Icotrokinra is a peptide that selectively binds to the IL-23 receptor (IL-23R) with a dissociation constant of 7 pM and antagonizes the binding of IL-23. IL-23 is a naturally occurring cytokine that is involved in inflammatory and immune responses. Icotrokinra inhibits the IL-23/IL-23R-dependent release of proinflammatory cytokines.

Targets

IL-23R

Storage

—

Approved

psoriasis — FDA

In trial

psoriasis

Sources

DailyMed (FDA label)DrugBank ClinicalTrials.gov

Last verified

2026-04-23

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