adapalene

small molecule

Mechanism of Action: Adapalene acts on retinoid receptors. Biochemical and pharmacological profile studies have demonstrated that adapalene is a modulator of cellular differentiation, keratinization, and inflammatory processes all of which represent important features in the pathology of acne vulgaris. Mechanistically, adapalene binds to specific retinoic acid nuclear receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene normalizes the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Retinoic acid receptor beta, Retinoic acid receptor gamma, Retinoic acid receptor RXR-beta, Retinoic acid receptor RXR-gamma, Retinoic acid receptor RXR-alpha, Transcription factor Jun, Toll-like receptor 2, Retinoic acid receptor alpha, Aspartate aminotransferase, cytoplasmic

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acne vulgaris — FDA

acne vulgaris

2026-04-19