difamilast

Modality

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Mechanism

12.1 Mechanism of Action Difamilast is an inhibitor of phosphodiesterase-4 (PDE-4). Difamilast’s inhibition of PDE-4 (a major cyclic adenosine monophosphate (AMP)-metabolizing enzyme) activity leads to accumulation of intracellular cyclic AMP and decreased productions of various cytokines and chemokines. However, the specific mechanism(s) by which difamilast exerts its therapeutic action is not well defined.

Targets

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Storage

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Approved

atopic dermatitis — FDA

In trial

atopic dermatitis

Sources

DailyMed (FDA label)ClinicalTrials.gov

Last verified

2026-06-14

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